Celiac & Gluten Sensitivity Testing

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If you’ve been experiencing digestive issues, unexplained fatigue, or skin problems after eating foods that contain wheat, the Celiac & Gluten Sensitivity Test can help you find answers. This blood test looks for specific antibodies that signal how your immune system is reacting to gluten. It can help identify celiac disease or point toward non-celiac gluten sensitivity.

You can order the Celiac & Gluten Sensitivity Test online through our secure platform—no clinic visit needed.

Test Description

The Celiac & Gluten Sensitivity Profile is a blood test that evaluates your immune response to gluten, a protein found in wheat, barley, and rye. This test measures specific antibodies—such as tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP)—that may be elevated if your body is reacting abnormally to gluten.

This panel is most often used to help detect celiac disease, an autoimmune condition where gluten triggers damage to the small intestine. Over time, this immune reaction can interfere with nutrient absorption and lead to a range of symptoms, including digestive discomfort, fatigue, skin rashes, nutrient deficiencies, and neurological issues. In some people, the damage occurs without obvious symptoms, which makes testing especially important.

The test can also offer insight into non-celiac gluten sensitivity, a condition where symptoms improve on a gluten-free diet even though celiac disease and wheat allergy are not present. While there is no definitive test for gluten sensitivity alone, antibody testing can help rule out celiac disease and support a more informed diagnosis.

This blood test is often recommended before beginning a gluten-free diet, as avoiding gluten before testing may reduce the accuracy of results. It is a useful tool for people with chronic digestive issues, unexplained fatigue, skin conditions, or a family history of autoimmune disease.

Markers

Here’s a simple explanation for each of the markers listed:

• Anti-DGP IgA: Looks for antibodies your body might produce against small gluten protein pieces. This can help identify celiac disease, especially if your immune system uses IgA.
• Anti-DGP IgG: Similar to Anti-DGP IgA, but focuses on IgG antibodies. It’s helpful if your body doesn’t make enough IgA.
• Anti-Gliadin IgA: Checks for antibodies to gliadin, a part of gluten. This test is older and less accurate but still used occasionally.
• Anti-Gliadin IgG: Looks for gliadin antibodies using IgG instead of IgA. This test may be used if your IgA levels are low.
• Anti-tTG IgA: One of the most reliable tests for celiac disease. It checks for antibodies to an enzyme involved in gluten digestion.
• Anti-tTG IgG: Similar to the IgA version but used when IgA levels are low or to confirm a result.
• Immunoglobulin A: Measures the amount of IgA in your blood. This is important because low IgA can affect how other tests work.
• Wheat: Looks for antibodies to wheat proteins. It can point to a wheat sensitivity but doesn’t confirm celiac disease.

Who Should Consider This Test?

• People with chronic digestive issues: Symptoms like bloating, diarrhea, or abdominal pain may be linked to celiac disease or gluten sensitivity, and antibody testing can help identify the cause.
• People with fatigue, joint pain, or skin rashes: Non-digestive symptoms may reflect immune reactions to gluten, even when gut symptoms are absent.
• People with a family history of celiac disease: First-degree relatives have a higher genetic risk and should consider testing even without symptoms.
• People with autoimmune diseases like type 1 diabetes or thyroid conditions: Celiac disease commonly occurs alongside other autoimmune disorders and may go undetected without testing.
• People with unexplained anemia, osteoporosis, or nutrient deficiencies: Gluten-triggered damage to the small intestine can interfere with iron, calcium, and vitamin absorption.
• People with dermatitis herpetiformis, eczema, or psoriasis: These skin conditions may improve with gluten removal if celiac disease or sensitivity is present.
• People with brain fog, nerve pain, or balance issues: Gluten-related inflammation can affect the nervous system and cause subtle or progressive neurological symptoms.
• Women with fertility challenges or recurrent miscarriage: Celiac disease may disrupt hormone function and nutrient absorption important for reproductive health.
• Children with developmental delays or attention concerns: Gluten intolerance may impair growth or cognitive function in children, especially when combined with nutrient malabsorption.
• People with chronic fatigue or fibromyalgia-like symptoms: Ongoing fatigue and body pain may be linked to immune or inflammatory responses triggered by gluten.
• People already avoiding gluten without a formal diagnosis: Testing after gluten reintroduction can confirm whether celiac disease or sensitivity is truly the underlying issue.
• People with IBS, gallbladder issues, or pancreatitis: These digestive complaints may overlap with gluten-related inflammation and merit further evaluation.
• People preparing for bariatric surgery: Testing can help identify pre-existing malabsorption issues that could affect outcomes after surgery.
• Older adults with new digestive complaints: Celiac disease can develop later in life and may be mistaken for other age-related digestive changes.
• People with frequent infections or autoimmune adrenal disorders: Chronic immune challenges may be worsened by undiagnosed celiac disease and benefit from screening.

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The information provided in this article is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Functional medical tests and nutrition-related labs should be used as tools to support health and wellness under the guidance of a qualified healthcare provider. Results from these tests should not replace professional medical advice or be interpreted without consulting a licensed practitioner familiar with your health history and needs. Always consult your doctor or dietitian before making changes to your diet, supplements, or health management plan.