From Leaky Gut to Stomach Ulcers: How the GI-Advanced Profile with Zonulin and H. pylori Can Help

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A GI-Advanced Profile, which includes tests for Zonulin and H. pylori, can help you better understand your digestive health. Zonulin is a protein that controls the tightness of your gut lining. Higher levels may point to issues like leaky gut, which can affect overall wellness. H. pylori, a common bacterium, is known for causing stomach ulcers and can lead to ongoing digestive discomfort if not addressed immediately. Ordering this test online offers a convenient, confidential way to monitor these key markers. You can order a GI Advanced Profile (with Zonulin and H. pylori) test online without a prescription.

Test Description

The GI-Advanced Profile examines the health of your gut microbiome, which is the group of microorganisms that live in your digestive system. These microorganisms are crucial for proper digestion, immune function, and overall health. When the balance of these microbes is disrupted, it can lead to various health issues, such as digestive problems, skin conditions, autoimmune diseases, and more.

The test includes multiple markers that offer a comprehensive look at your gut health. It also includes key markers like Zonulin and H. pylori, which provide important information about how your gut is functioning. Zonulin is a protein that controls how open or tight the gut lining is. If Zonulin levels are too high, it can signal “leaky gut,” where the gut lining becomes too porous. This allows harmful substances to leak into the bloodstream, causing inflammation and possibly leading to other health problems.

H. pylori is a type of bacteria found in the stomach. While it doesn’t cause problems for everyone, it can lead to stomach ulcers and long-term inflammation if left untreated. Testing for H. pylori can help identify the cause of digestive issues, like ulcers or gastritis.

By looking at these markers, the GI-Advanced Profile can help spot potential problems in your gut health. Knowing more about your gut function can help you take steps to restore balance, reduce inflammation, and improve digestion, supporting better health in the long run.

Markers

Acetate: Acetate is a short-chain fatty acid produced when gut bacteria break down fiber in the diet. It plays a key role in maintaining gut health by supporting the gut lining and promoting a healthy inflammatory response.
Actinobacteria: Actinobacteria are a group of beneficial bacteria that help break down complex carbohydrates and fiber in the gut. They play an important role in digestion and maintaining a healthy balance of gut bacteria.
Adenovirus 40/41: These are types of viruses that can infect the gastrointestinal tract, causing symptoms like diarrhea, vomiting, and stomach cramps. They are commonly spread through contaminated food or water, especially in children.
Aeromonas hydrophila: This bacterium is typically found in water and food, but it can cause gastrointestinal infections if ingested. It is associated with symptoms like diarrhea, abdominal cramps, and nausea, especially in immunocompromised individuals.
Akkermansia muciniphila: Akkermansia muciniphila is a beneficial bacterium that helps maintain the gut lining by breaking down mucin, a component of mucus. It is associated with better metabolic health, immune function, and reduced inflammation.
Ancylostoma duodenale: A type of hookworm, Ancylostoma duodenale can infect the intestines and cause symptoms such as abdominal pain, diarrhea, and anemia. It is usually contracted through contaminated soil or feces.
Antibiotic Sensitivities: This test identifies which antibiotics are effective against harmful bacteria in the gut. It helps doctors choose the best treatment for bacterial infections while avoiding unnecessary antibiotic use.
Antifungal Sensitivities: This test determines which antifungal medications are effective against fungi in the gut, such as yeast infections caused by Candida. It is important for guiding treatment of fungal overgrowths or infections.
Ascaris lumbricoides: Ascaris lumbricoides is a large parasitic roundworm that lives in the intestines and can cause symptoms like abdominal discomfort, malnutrition, and coughing. It is contracted through the ingestion of contaminated food or water.
Astrovirus: Astroviruses are viruses that cause gastroenteritis, typically leading to symptoms such as diarrhea, nausea, and vomiting. They are commonly spread through contaminated food and water, especially in children.
Bacillus spp.: Bacillus species are a group of bacteria that can be found in the gut and environment. While many of these bacteria are harmless or even beneficial, some can cause food poisoning and other infections.
Bacteria Culture: A bacteria culture is a lab test that grows bacteria from a sample to identify harmful pathogens. This helps determine the cause of infections, including digestive issues or urinary tract infections, and guides appropriate treatment.
Bacteroides fragilis: Bacteroides fragilis is a common bacterium in the human gut that helps break down food and maintain digestive health. While generally beneficial, it can cause infections if it enters the bloodstream or other parts of the body.
Bacteroidetes: Bacteroidetes are a group of bacteria that are essential for digesting complex carbohydrates and fibers. They play a vital role in maintaining gut health and a balanced microbiome.
Beta-Glucuronidase: Beta-glucuronidase is an enzyme produced by gut bacteria that helps in breaking down toxins and compounds in the digestive system. Elevated levels of this enzyme can be associated with digestive issues or an imbalance in gut bacteria.
Bifidobacterium adolescentis: Bifidobacterium adolescentis is a beneficial bacterium that helps break down dietary fiber and supports gut health. It plays an important role in maintaining a balanced microbiome, promoting digestion, and supporting the immune system.
Bifidobacterium bifidum: Bifidobacterium bifidum is a type of good bacteria that supports digestion by breaking down fibers and sugars in the intestines. It helps protect against harmful microbes and supports overall immune health.
Bifidobacterium breve: Bifidobacterium breve is a strain of beneficial bacteria that contributes to the healthy digestion of food, especially fibers. It also helps maintain a balanced gut microbiome and reduces inflammation in the digestive system.
Bifidobacterium longum: Bifidobacterium longum is a probiotic bacterium that supports gut health by improving digestion, reducing inflammation, and strengthening the immune system. It is commonly found in the intestines and plays a role in preventing gut-related illnesses.
Blastocystis hominis: Blastocystis hominis is a protozoan parasite that can be present in the intestines without causing symptoms, but in some cases, it may lead to digestive issues such as diarrhea, bloating, or abdominal pain. It is typically spread through contaminated food or water.
Butyrate: Butyrate is a short-chain fatty acid produced by beneficial bacteria in the gut during the digestion of fiber. It supports gut health by nourishing the gut lining, reducing inflammation, and improving overall digestive function.
Calprotectin: Calprotectin is a protein found in the stool that acts as an indicator of inflammation in the intestines. Elevated levels are often associated with conditions like inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis.
Campylobacter spp.: Campylobacter species are bacteria that can cause food poisoning, leading to symptoms like diarrhea, fever, and stomach cramps. It is commonly contracted from undercooked poultry or contaminated water.
Candida albicans: Candida albicans is a type of yeast that naturally lives in the digestive tract but can overgrow and cause infections like thrush, vaginal yeast infections, or digestive issues if the balance of gut flora is disturbed.
Candida dubliniensis: Candida dubliniensis is a yeast that is similar to Candida albicans and can cause infections, especially in people with weakened immune systems. It is typically found in the mouth and throat but can spread to other parts of the body.
Candida famata: Candida famata is a yeast species that is generally harmless in the gut but can cause infections in certain circumstances. Overgrowth of this yeast can lead to digestive discomfort or other health issues.
Candida glabrata: Candida glabrata is a type of yeast that can cause infections, particularly in immunocompromised individuals. It can lead to conditions such as oral thrush, vaginal infections, and other systemic infections.
Candida intermedia: Candida intermedia is a type of yeast that can occasionally cause infections, particularly in people with weakened immune systems. It is often found in the gastrointestinal tract but can cause problems if allowed to overgrow.
Candida kefyr: Candida kefyr is a yeast species that can be found in fermented foods, such as kefir. It can lead to infections, particularly in people with compromised immune systems or those who have a disrupted balance of gut bacteria.
Candida krusei: Candida krusei is a yeast that can cause infections, particularly in hospital patients or those with weakened immune systems. It is often resistant to certain antifungal treatments, making it more challenging to treat.
Candida lambica: Candida lambica is a rare yeast species that can cause infections in people with underlying health conditions or weakened immune systems. It is less common but can lead to issues like oral thrush and digestive discomfort.
Candida lipolytica: Candida lipolytica is a type of yeast that can cause infections, particularly in people with weakened immune systems. It is typically found in the gastrointestinal tract but can cause systemic issues if it spreads.
Candida lusitaniae: Candida lusitaniae is a type of yeast that can cause infections in immunocompromised individuals, often in hospital settings. It can be resistant to certain antifungal medications, making treatment more difficult.
Candida parapsilosis: Candida parapsilosis is a yeast species that can cause infections, especially in patients with compromised immune systems or those in healthcare settings. It is often associated with skin, bloodstream, and gastrointestinal infections.
Citrobacter freundii: Citrobacter freundii is a bacterium that can cause infections, particularly in the gastrointestinal and urinary tracts. It can lead to symptoms such as diarrhea, abdominal pain, and urinary tract infections.
Citrobacter spp.: Citrobacter species are bacteria that can cause infections in various parts of the body, including the gut. These bacteria are commonly associated with gastrointestinal issues, urinary tract infections, and sepsis in vulnerable individuals.
Clostridium difficile: Clostridium difficile is a harmful bacterium that can cause severe diarrhea and inflammation in the colon, particularly after the use of antibiotics. It can lead to life-threatening conditions such as colitis and sepsis if not treated properly.
Clostridium difficile Toxin A: Toxin A is a protein produced by C. difficile that causes damage to the intestines, leading to inflammation and symptoms like diarrhea. It plays a key role in the severity of C. difficile infections.
Clostridium difficile Toxin B: Toxin B is another toxin produced by C. difficile that contributes to severe intestinal damage and inflammation. It is a major factor in the symptoms of C. difficile infections, including abdominal pain and diarrhea.
Clostridium spp.: Clostridium species are a group of bacteria that can cause a variety of infections, including botulism, food poisoning, and gastrointestinal issues. Some strains are harmful, while others are part of the normal gut flora.
Cryptosporidium spp.: Cryptosporidium species are parasitic organisms that can cause gastrointestinal illness, including diarrhea and stomach cramps. They are often spread through contaminated water sources.
Desulfovibrio piger: Desulfovibrio piger is a bacterium found in the gut that can contribute to the breakdown of certain compounds. It may be linked to conditions involving high-protein diets or gastrointestinal disturbances.
Dientamoeba fragilis: Dientamoeba fragilis is a parasitic organism that can cause gastrointestinal symptoms, including diarrhea, bloating, and stomach cramps. It is typically spread through contaminated food or water.
E. coli O157: E. coli O157 is a harmful strain of Escherichia coli that can cause severe food poisoning, leading to symptoms like diarrhea (sometimes bloody), stomach cramps, and vomiting. It is often found in undercooked beef and contaminated water.
Endolimax nana: Endolimax nana is a type of amoeba that typically lives in the intestines without causing symptoms. In some cases, it may cause mild gastrointestinal discomfort, but it is generally considered harmless.
Entamoeba coli: Entamoeba coli is a non-pathogenic amoeba that resides in the human intestines. While it usually does not cause illness, its presence can indicate poor hygiene or contaminated food and water.
Entamoeba histolytica: Entamoeba histolytica is a parasitic amoeba that can cause amoebic dysentery, leading to severe diarrhea, abdominal pain, and blood in the stool. It is typically transmitted through contaminated food or water.
Enteroaggregative E. coli: Enteroaggregative E. coli is a strain of bacteria that causes gastrointestinal infections, characterized by watery diarrhea and abdominal cramps. It adheres to the intestinal lining in a unique pattern, leading to chronic diarrhea in some cases.
Enterobius vermicularis: Enterobius vermicularis, also known as the pinworm, is a parasitic worm that infects the intestines, especially in children. It causes itching around the anus and can lead to discomfort, sleep disturbances, and digestive issues.
Enterococcus faecalis: Enterococcus faecalis is a type of bacteria commonly found in the intestines, where it helps with digestion. However, if it enters other parts of the body, it can cause infections such as urinary tract infections or endocarditis.
Enterococcus faecium: Enterococcus faecium is another type of intestinal bacteria that can be beneficial in small amounts. Infections caused by Enterococcus faecium are common in hospital settings, particularly among those with weakened immune systems.
Enterococcus spp.: Enterococcus species are a group of bacteria that are normally found in the intestines and can aid in digestion. While they are typically harmless, some species can cause infections, particularly in hospital environments.
Enterohemorrhagic E. coli: Enterohemorrhagic E. coli (EHEC) is a strain that causes severe illness, including bloody diarrhea and abdominal cramps. It is commonly associated with contaminated food, particularly undercooked ground beef, and can lead to kidney failure in severe cases.
Enteroinvasive E. coli/Shigella: Enteroinvasive E. coli and Shigella are bacteria that cause dysentery, leading to symptoms like bloody diarrhea, fever, and abdominal cramps. They invade the intestinal lining, leading to inflammation and tissue damage.
Enteropathogenic E. coli: Enteropathogenic E. coli (EPEC) is a type of bacteria that causes diarrhea, especially in young children. It adheres to the intestinal cells and disrupts their function, leading to watery diarrhea and dehydration.
Enterotoxigenic E. coli: Enterotoxigenic E. coli (ETEC) is a strain of bacteria that produces toxins, leading to traveler’s diarrhea, nausea, and abdominal cramping. It is often spread through contaminated food and water.
Escherichia spp.: Escherichia species are a group of bacteria, including the well-known E. coli. While many strains are harmless and live in the intestines, some can cause serious infections and gastrointestinal illnesses.
Euryarchaeota: Euryarchaeota is a group of archaea (microorganisms similar to bacteria) that can be found in various environments, including the gut. Some species help with digestion, while others may be linked to certain digestive disorders.
Faecalibacterium prausnitzii: Faecalibacterium prausnitzii is a beneficial bacterium that helps maintain a healthy gut by producing butyrate, a short-chain fatty acid that reduces inflammation. A lower presence of this bacterium is often associated with inflammatory bowel diseases (IBD).
Firmicutes: Firmicutes is a large group of bacteria that are important for digesting food and maintaining a balanced gut microbiome. A higher ratio of Firmicutes to other bacteria has been linked to obesity and other metabolic conditions.
Firmicutes/Bacteroidetes Ratio: This ratio compares the abundance of two major groups of gut bacteria: Firmicutes and Bacteroidetes. An imbalance in this ratio is thought to be associated with conditions such as obesity, diabetes, and inflammatory bowel disease.
Fusobacterium spp.: Fusobacterium species are bacteria found in the mouth and intestines. Some species of Fusobacterium are linked to infections, while others may contribute to conditions like colorectal cancer.
Geotrichum spp.: Geotrichum species are fungi that can be found in the gut, as well as in food and the environment. While they are usually harmless, an overgrowth can sometimes cause infections or digestive discomfort.
Giardia: Giardia is a parasitic microorganism that causes giardiasis, leading to symptoms such as diarrhea, cramps, and bloating. It is typically transmitted through contaminated water or food.
H. pylori Virulence Factor babA: The babA gene in Helicobacter pylori bacteria is associated with the bacteria’s ability to adhere to the stomach lining. This adhesion is critical for the infection process and is linked to more severe stomach ulcers and gastritis.
H. pylori Virulence Factor cagA: cagA is a gene in Helicobacter pylori that encodes a protein linked to increased inflammation in the stomach. Its presence is associated with a higher risk of stomach cancer and more severe peptic ulcers.
H. pylori Virulence Factor dupA: dupA is another gene found in Helicobacter pylori that is thought to contribute to the severity of infection. It is linked to a greater risk of gastric ulcers and chronic inflammation in the stomach lining.
H. pylori Virulence Factor iceA: The iceA gene in Helicobacter pylori is associated with the bacterium’s ability to evade the immune system and contribute to more severe infections. Its presence can increase the risk of chronic gastritis and stomach ulcers.
H. pylori Virulence Factor oipA: oipA is a gene in Helicobacter pylori that is involved in the bacterium’s ability to adhere to stomach cells. It plays a role in the development of gastric diseases, including ulcers and cancer.
H. pylori Virulence Factor vacA: The vacA gene produces a toxin that damages stomach cells and leads to inflammation. This toxin is a major factor in the development of ulcers and is associated with a higher risk of stomach cancer.
H. pylori Virulence Factor virB: virB is a gene in Helicobacter pylori that helps the bacterium inject toxins into stomach cells, promoting infection and inflammation. It plays a key role in the severity of infections caused by H. pylori.
H. pylori Virulence Factor virD: virD is involved in the genetic transfer of virulence factors in H. pylori. It contributes to the bacterium’s ability to cause chronic infection and complications such as ulcers or stomach cancer.
Helicobacter pylori: Helicobacter pylori is a bacterium that can infect the stomach, leading to conditions such as gastritis, peptic ulcers, and stomach cancer. It is commonly acquired in childhood and often persists for years if untreated.
Klebsiella pneumoniae: Klebsiella pneumoniae is a bacterium that can cause pneumonia, urinary tract infections, and sepsis. It is especially problematic in hospital settings and among people with weakened immune systems.
Klebsiella spp.: Klebsiella species are bacteria that can cause various infections, including pneumonia, urinary tract infections, and bloodstream infections. They are often resistant to antibiotics, making treatment more difficult.
Lactobacillus acidophilus: Lactobacillus acidophilus is a type of beneficial bacteria found in the gut and in probiotic foods like yogurt. It helps with digestion, supports the immune system, and maintains a healthy balance of gut flora.
Lactobacillus casei: Lactobacillus casei is a probiotic bacterium that helps maintain a healthy gut microbiome. It supports digestion, improves lactose tolerance, and may help reduce inflammation in the intestines.
Lactobacillus delbrueckii: Lactobacillus delbrueckii is a bacterium used in the fermentation of dairy products, contributing to the production of lactic acid. It plays a role in maintaining gut health and promoting a balanced microbiome.
Lactobacillus plantarum: Lactobacillus plantarum is a type of probiotic bacterium that helps with digestion and maintains a healthy balance of gut flora. It is often found in fermented foods like sauerkraut and pickles.
Lactobacillus rhamnosus: Lactobacillus rhamnosus is a well-known probiotic bacterium that supports gut health, boosts the immune system, and helps prevent infections. It is often used in probiotic supplements.
Lactobacillus salivarius: Lactobacillus salivarius is a beneficial bacterium that supports digestion and helps protect against harmful pathogens. It is found in the gut and is sometimes used in probiotic therapies.
Methanobacteriaceae: Methanobacteriaceae are archaea that produce methane as a byproduct of digestion. These microbes are common in the gut and play a role in breaking down food, especially in the large intestine.
Morganella spp.: Morganella species are bacteria that can be found in the intestines and occasionally cause infections, including urinary tract infections and wounds. They are typically treated with antibiotics.
Mucus: Mucus is a sticky, gel-like substance produced by the cells lining the intestines. It plays an important role in protecting the gut lining from harmful pathogens and aids in the smooth movement of food through the digestive system.
Natural Antifungal Sensitivities: This test identifies which natural antifungal treatments are effective against fungal infections in the gut. It helps guide treatment options for conditions caused by fungal overgrowth, such as Candida infections.
Natural Inhibitor Sensitivities: This test examines how effective natural inhibitors, such as plant compounds, are at fighting off harmful bacteria, fungi, or viruses in the gut. It provides insights into using natural treatments to restore gut balance and prevent infections.
Necator americanus: Necator americanus is a type of hookworm that can infect the intestines, leading to symptoms such as abdominal pain, diarrhea, and iron-deficiency anemia. It is typically contracted through contaminated soil.
Norovirus GI: Norovirus GI is a strain of the norovirus that causes gastrointestinal infections, leading to symptoms like vomiting, diarrhea, and stomach cramps. It is highly contagious and often spread through contaminated food or water.
Norovirus GII: Norovirus GII is another strain of norovirus, responsible for outbreaks of gastroenteritis, particularly in closed environments like cruise ships or schools. Symptoms include nausea, vomiting, and diarrhea.
Occult Blood: Occult blood refers to hidden blood in the stool, which can be an indicator of gastrointestinal issues like ulcers, hemorrhoids, or more serious conditions such as colorectal cancer. It can be detected through stool testing.
Oxalobacter formigenes: Oxalobacter formigenes is a bacterium that helps break down oxalates in the intestines, preventing the formation of kidney stones. A deficiency of this bacterium can contribute to higher oxalate levels in the body.
Pancreatic Elastase 1: Pancreatic elastase 1 is an enzyme produced by the pancreas that helps digest food. Low levels of this enzyme in stool can indicate pancreatic insufficiency, which can impair digestion and nutrient absorption.
Pentatrichomonas hominis: Pentatrichomonas hominis is a type of protozoan parasite that lives in the intestines. While usually harmless, it can cause mild gastrointestinal discomfort, including diarrhea and bloating.
Prevotella copri: Prevotella copri is a bacterium found in the gut that is involved in the breakdown of carbohydrates and other nutrients. An overgrowth of this bacterium may be linked to conditions like inflammatory bowel disease (IBD) and metabolic disorders.
Propionate: Propionate is a short-chain fatty acid produced by gut bacteria during the fermentation of fiber. It helps maintain a healthy gut environment by supporting gut barrier function and reducing inflammation.
Proteobacteria: Proteobacteria are a group of bacteria that are found in the gut but can cause problems when they become overrepresented. An overgrowth of Proteobacteria is often associated with gut inflammation and diseases like IBD.
Proteus mirabilis: Proteus mirabilis is a bacterium that can cause urinary tract infections (UTIs) and other infections, including in the gastrointestinal tract. It is known for its ability to form biofilms and resist certain antibiotics.
Proteus spp.: Proteus species are a group of bacteria found in the gut, some of which can cause infections, particularly in the urinary tract or wounds. They can also contribute to conditions like kidney stones.
Pseudomonas aeruginosa: Pseudomonas aeruginosa is a type of bacteria that can cause infections in the lungs, urinary tract, and other parts of the body. It is often resistant to antibiotics and is a common concern in hospital settings.
Pseudomonas spp.: Pseudomonas species are bacteria that can cause infections, particularly in immunocompromised individuals. They are commonly found in the environment and can affect the respiratory, urinary, and digestive systems.
Rhodotorula spp.: Rhodotorula species are yeasts that can be found in the gastrointestinal tract. While typically harmless, an overgrowth can lead to fungal infections, especially in individuals with weakened immune systems.
Rotavirus A: Rotavirus A is a virus that causes gastroenteritis, especially in young children, leading to severe diarrhea, vomiting, and dehydration. It is highly contagious and can spread through contaminated food and water.
Saccharomyces cerevisiae: Saccharomyces cerevisiae is a type of yeast commonly used in baking and brewing. It is generally harmless in the gut but can contribute to fungal infections when overgrown, especially in people with compromised immunity.
Salmonella spp.: Salmonella species are bacteria that cause food poisoning, leading to symptoms like diarrhea, abdominal cramps, and fever. It is commonly transmitted through contaminated food, particularly poultry and eggs.
Sapovirus I: Sapovirus I is a virus that causes gastroenteritis, leading to symptoms such as diarrhea and vomiting. It is spread through contaminated food and water, particularly in winter months.
Sapovirus II: Sapovirus II is another strain of the sapovirus virus, which causes stomach infections. It spreads easily through contaminated food, water, or contact with infected individuals.
Sapovirus IV: Sapovirus IV is a less common strain of sapovirus that causes similar symptoms, including vomiting and diarrhea. It is part of the family of viruses that contribute to gastroenteritis outbreaks.
Sapovirus V: Sapovirus V is another strain in the sapovirus family, known for causing outbreaks of stomach illnesses, including diarrhea and vomiting. It spreads easily through contaminated food and water.
Secretory IgA: Secretory IgA is an antibody found in mucous membranes, including the gut. It plays a key role in protecting the digestive system from pathogens and maintaining immune health in the gut.
Shiga-like Toxin E. coli stx1: Shiga-like toxin stx1 is produced by some strains of E. coli and can damage the lining of the intestines, leading to severe diarrhea and potential kidney damage. It is a major factor in the severity of foodborne illness caused by E. coli.
Shiga-like Toxin E. coli stx2: Shiga-like toxin stx2 is another toxin produced by certain E. coli strains, contributing to more severe symptoms, including bloody diarrhea, kidney failure, and hemolytic uremic syndrome (HUS).
Staphylococcus aureus: Staphylococcus aureus is a bacterium that can cause a variety of infections, including food poisoning, skin infections, and respiratory infections. It produces toxins that can lead to severe illness when ingested.
Staphylococcus spp.: Staphylococcus species are bacteria that can cause infections in various parts of the body, including the skin, lungs, and gastrointestinal tract. Some strains are resistant to antibiotics, making treatment challenging.
Steatocrit: Steatocrit measures the amount of fat in stool, which can indicate malabsorption or digestive issues. A high steatocrit level may suggest problems with fat digestion or conditions like pancreatic insufficiency.
Streptococcus agalactiae: Streptococcus agalactiae, also known as Group B Streptococcus, can cause infections in newborns and pregnant women, including pneumonia and sepsis. It is often screened for during pregnancy to prevent transmission during childbirth.
Streptococcus anginosus: Streptococcus anginosus is a bacterium found in the mouth and intestines. While it is normally harmless, it can cause infections, particularly in the abscesses or other areas where it is not typically present.
Streptococcus aureus: Streptococcus aureus is a harmful bacterium that can cause serious infections, including pneumonia, skin infections, and food poisoning. It is capable of producing toxins and is often resistant to antibiotics.
Streptococcus mutans: Streptococcus mutans is a bacterium found in the mouth that plays a role in the development of dental cavities. It produces acid from sugars, which can erode tooth enamel.
Streptococcus oralis: Streptococcus oralis is a bacterium found in the mouth and throat that can contribute to oral health problems, including dental infections and gum disease.
Streptococcus salivarius: Streptococcus salivarius is a beneficial bacterium found in the mouth and throat. It helps protect against harmful bacteria by producing antimicrobial compounds and maintaining oral health.
Streptococcus spp.: Streptococcus species are a group of bacteria found in the mouth and respiratory tract. While some species are harmless, others can cause throat infections, pneumonia, or skin infections.
Strongyloides stercoralis: Strongyloides stercoralis is a parasitic worm that can cause a condition known as strongyloidiasis. It can lead to symptoms like abdominal pain, diarrhea, and skin rashes and is typically contracted through contaminated soil.
Taenia spp.: Taenia species, also known as tapeworms, can infect the intestines and cause symptoms like weight loss, abdominal pain, and digestive disturbances. Infection occurs through ingestion of undercooked or contaminated meat.
Transglutaminase IgA: Transglutaminase IgA is an antibody that is often tested in people suspected of having celiac disease. Elevated levels suggest an immune reaction to gluten, which can damage the small intestine and impair nutrient absorption.
Trichuris trichiura: Trichuris trichiura, also known as the whipworm, is a parasitic worm that can infect the intestines, causing symptoms like diarrhea, abdominal pain, and anemia. It is contracted through contaminated food or water.
Valerate: Valerate is a short-chain fatty acid produced in the gut during the fermentation of fiber. It helps promote gut health by supporting the intestinal lining and reducing inflammation.
Verrucomicrobia: Verrucomicrobia is a phylum of bacteria found in the gut that can influence gut health and metabolism. Some species may help regulate the immune system and prevent inflammation.
Vibrio spp.: Vibrio species are bacteria that can cause foodborne illnesses, particularly from eating contaminated seafood. Symptoms of infection include diarrhea, nausea, and vomiting, and can be severe in immunocompromised individuals.
Yeast Culture: Yeast culture is a laboratory test that grows yeast from a sample to identify species and determine potential infections. It helps detect fungal overgrowth, such as Candida, that could be causing symptoms in the gut or other parts of the body.
Yersinia enterocolitica: Yersinia enterocolitica is a bacterium that can cause gastrointestinal illness, leading to symptoms like diarrhea, fever, and abdominal pain. It is typically spread through contaminated food, especially pork.
Zonulin: Zonulin is a protein that helps regulate the permeability of the intestinal lining. High levels of Zonulin are associated with leaky gut, where harmful substances can enter the bloodstream and contribute to inflammation and autoimmune conditions.
pH: pH measures the acidity or alkalinity of a substance, such as the gut. The pH of the stool can provide insights into gut health, with abnormal levels often indicating imbalances in gut bacteria or digestive issues.

Who Should Consider This Test?

Individuals with gastrointestinal symptoms: People who experience chronic digestive issues such as bloating, abdominal pain, diarrhea, or constipation might benefit from the GI-Advanced Profile. This test can help identify potential underlying gut imbalances, including issues with Zonulin (indicating leaky gut) and harmful bacteria like H. pylori, which could be contributing to their symptoms.
People with food sensitivities or allergies: Those who suspect food intolerances or sensitivities, such as to gluten, dairy, or specific carbohydrates, may want to consider this test. Zonulin levels can indicate increased intestinal permeability, often associated with food sensitivities, while identifying H. pylori infections may also help pinpoint underlying causes of digestive discomfort after consuming certain foods.
Individuals with autoimmune conditions: People with autoimmune diseases such as rheumatoid arthritis, celiac disease, or Hashimoto’s thyroiditis may benefit from this test to evaluate their gut health. An imbalance in the gut microbiome or increased Zonulin levels can play a role in the development and exacerbation of autoimmune conditions by triggering inflammation and immune responses.
Individuals with a history of frequent antibiotic use: Those who have taken antibiotics regularly or for extended periods may experience gut microbiome disruptions. The GI-Advanced Profile can help assess the health of the gut microbiome and detect any imbalances, such as an overgrowth of harmful bacteria or a compromised gut lining, which may have resulted from antibiotic use.
People with a family history of gastrointestinal disorders: Individuals with a family history of gastrointestinal diseases such as Crohn’s disease, ulcerative colitis, or irritable bowel syndrome (IBS) may consider this test for early detection. Zonulin levels and gut microbiome imbalances can provide valuable information about a person’s susceptibility to developing similar digestive issues in the future.
People with unexplained fatigue or mood disorders: Individuals suffering from chronic fatigue, depression, or anxiety may find value in testing for gut health markers. Research suggests a link between gut health and mental well-being, and disruptions in the gut microbiome or the presence of H. pylori may contribute to mood disorders and fatigue.
Individuals with chronic inflammation or autoimmune diseases: Those experiencing chronic inflammation or autoimmune diseases might consider this test to check for high Zonulin levels, which indicate leaky gut. Increased gut permeability can contribute to systemic inflammation and immune dysfunction, often exacerbating autoimmune conditions.
Individuals experiencing recurrent or chronic infections: People who suffer from frequent or chronic gastrointestinal infections should consider the GI-Advanced Profile to identify underlying causes, such as H. pylori infection or microbiome imbalances. Understanding the state of gut health can help guide treatment and prevent recurrent infections.
People who have undergone gastrointestinal surgeries: After undergoing surgeries like gastric bypass or other gut-related procedures, individuals may experience changes in their gut health. The GI-Advanced Profile can help assess the microbiome and gut permeability, aiding in post-surgery recovery and identifying any imbalances that may require attention.
Individuals who consume a high-sugar or highly processed diet: Diets rich in sugar or processed foods can negatively affect the gut microbiome, leading to bacterial imbalances and inflammation. Testing the gut with this test can help assess the impact of diet on gut health and identify potential imbalances contributing to digestive problems or overall discomfort.
People with metabolic conditions or obesity: Individuals with metabolic disorders such as diabetes, insulin resistance, or obesity may benefit from this test to better understand the role of gut health in their condition. Imbalances in gut bacteria and increased Zonulin levels have been linked to metabolic diseases and inflammation, so identifying these issues early could help improve management of these conditions.
People on a restricted or elimination diet: Those following strict or elimination diets, such as a gluten-free or low FODMAP diet, may experience changes in gut health that the GI-Advanced Profile can help track. The test can reveal how these diets are affecting gut microbiome diversity, gut permeability, and overall digestive function.
Individuals with chronic stress or anxiety: People dealing with chronic stress or anxiety may want to assess their gut health, as stress has been shown to impact gut microbiome diversity and permeability. The GI-Advanced Profile can help identify markers like Zonulin and H. pylori that could be contributing to gut issues or mental health concerns.
People with unexplained weight gain or difficulty losing weight: Those struggling with unexplained weight gain or finding it difficult to lose weight despite efforts may benefit from this test. An imbalanced gut microbiome or high Zonulin levels can disrupt metabolism and contribute to weight-related issues, making this test useful for identifying potential causes.
Individuals exposed to environmental toxins or pollutants: People living in environments with high levels of toxins or pollutants may experience disruptions in their gut health. The GI-Advanced Profile can help detect imbalances in the microbiome or damage to the gut lining that could be linked to environmental stressors.
Individuals with chronic antibiotic resistance infections: People who have had repeated or difficult-to-treat infections, especially those resistant to antibiotics, may benefit from the GI-Advanced Profile. The test can help identify bacterial imbalances or resistant pathogens in the gut that may be contributing to ongoing health issues.
Individuals undergoing chemotherapy or immunosuppressive treatment: People who are undergoing chemotherapy or immunosuppressive treatments may have weakened immune systems and may experience disruptions in their gut health. This test can help assess the gut microbiome’s condition and detect any imbalances or infections that could worsen during treatment.
People with frequent or recurring fungal infections: Individuals who suffer from frequent fungal infections, such as yeast infections or systemic fungal infections, could benefit from the test. The GI-Advanced Profile can identify imbalances in the gut microbiome that may promote fungal overgrowth, including Candida species.
Individuals with persistent bloating or digestive discomfort after meals: People who experience bloating, discomfort, or fullness after eating may have underlying gut issues that the GI-Advanced Profile can help identify. This could include bacterial imbalances, H. pylori infection, or gut permeability problems that are contributing to these symptoms.
People with a sedentary lifestyle: Individuals with limited physical activity may experience gut health issues related to poor digestion and microbiome imbalances. Testing their gut with the GI-Advanced Profile could help identify potential disruptions and provide guidance for improving gut health through diet, exercise, and other interventions.
Individuals with a history of traveler’s diarrhea or travel-related gastrointestinal illnesses: Those who have experienced gastrointestinal illness while traveling, especially in areas with lower sanitation standards, may want to test their gut health. The GI-Advanced Profile can identify lingering pathogens like H. pylori or changes in gut microbiome composition that could affect overall health after an infection.
Individuals with chronic diarrhea or constipation: Those with long-standing issues related to either chronic diarrhea or constipation may find the GI-Advanced Profile useful in pinpointing the cause. Testing for gut microbiome imbalances, Zonulin levels, and H. pylori can reveal underlying issues affecting bowel movements and digestive regularity.
People with a history of inflammatory bowel disease (IBD) flare-ups: Individuals with Crohn’s disease, ulcerative colitis, or other forms of IBD may want to use the GI-Advanced Profile to monitor their gut health. This test can help detect flare-ups, identify bacterial imbalances, and assess Zonulin levels, which are often elevated in inflammatory conditions.
Individuals with chronic or recurrent skin infections: People who experience persistent skin infections or conditions like eczema, acne, or psoriasis may want to explore their gut health. Imbalances in the gut microbiome and increased Zonulin levels have been linked to skin health, and this test can help identify underlying issues.
People with neurological conditions: Individuals with neurological conditions like migraines, autism spectrum disorders, or multiple sclerosis (MS) may consider testing their gut health. Research has shown that the gut-brain connection is strong, and disruptions in the microbiome or gut permeability can influence these conditions.
Individuals with hormonal imbalances: People experiencing unexplained hormonal imbalances, such as irregular menstrual cycles, thyroid issues, or unexplained weight gain, may benefit from testing their gut health. A compromised gut microbiome and elevated Zonulin levels can interfere with hormone regulation and metabolism.
Vegetarians or vegans with digestive issues: Those following vegetarian or vegan diets may face challenges related to nutrient absorption or digestive discomfort, especially if they are not getting enough fiber or other essential nutrients. The GI-Advanced Profile can assess gut health, identify nutrient malabsorption, and provide insights into potential gut imbalances.
People who consume a high-fat diet: A diet high in fats can alter the gut microbiome and contribute to gut permeability. Individuals on a high-fat diet who are experiencing digestive discomfort, inflammation, or other health concerns may benefit from testing for Zonulin levels and overall gut health.
Individuals with a history of gastrointestinal cancer: Those who have had gastrointestinal cancers such as colon, stomach, or esophageal cancer may want to track their gut health post-treatment. The GI-Advanced Profile can help monitor gut microbiome recovery and identify any imbalances that may contribute to long-term digestive issues.
People dealing with chronic sinus infections: Chronic sinus infections or rhinosinusitis may be linked to gut health, as an imbalance in the gut microbiome can affect the immune system. Testing the gut could provide insights into potential sources of chronic inflammation that might be contributing to persistent sinus issues.
Individuals with a history of liver or gallbladder disease: People with liver or gallbladder conditions, such as fatty liver disease, cirrhosis, or gallstones, may benefit from this test to evaluate how their gut health is influencing liver function. The microbiome plays a role in liver health, and Zonulin levels can indicate whether there is an issue with gut permeability that could impact overall liver function.
People with chronic or unexplained joint pain: Chronic joint pain, particularly in the absence of an obvious injury or diagnosis, may be linked to gut health. A compromised gut microbiome and high Zonulin levels are associated with systemic inflammation, which can contribute to joint pain and discomfort.
Athletes with digestive issues or performance concerns: Athletes who experience digestive discomfort, fatigue, or immune system stress may find the GI-Advanced Profile helpful. Gut health directly impacts energy levels, immune function, and inflammation, all of which are crucial for performance and recovery in sports.

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The information provided in this article is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Functional medical tests and nutrition-related labs should be used as tools to support health and wellness under the guidance of a qualified healthcare provider. Results from these tests should not replace professional medical advice or be interpreted without consulting a licensed practitioner familiar with your health history and needs. Always consult your doctor or dietitian before making changes to your diet, supplements, or health management plan.